It depends on the individual.
Introverts, for example, may love it. Most introverts enjoy friends, but limit their circle to a few people.
However, if someone has no friends, it can be difficult. Especially when it is in conjunction with bullying, the result is often low self-esteem and depression. That being said, having too many friends can be just as bad; they will likely fight amongst themselves and force you to side with them, and you will often feel as if you are being pulled in multiple directions. Having one or two best friends will allow you to form meaningful relationships, without the drama.
Try to remain receptive towards your buddies, though, as that may very well influence their opinion of you.
Thanks for following.